I love House so much, It's my favorite show on TV followed by the office, (although the office has started to suck imo), and it's remained great all these years.
Hugh Laurie was also in a pretty funny sketch comedy show called "A Bit of Fry and Laurie" which I bought on DVD and it's pretty damn funny, it's sort of weird seeing House be a comedian though lol.
IMO the funniest moment in House is when Stacy wants House to treat her husband, and House's team says he can't do the treatment because it's too risky, and stand in the way, and House says something to Stacy like, "Well now what are we going to do? I have an idea, you grab the big dark one, I'll grab the little girl, and the Aussie will run away crying like a scared wombat" lol I laughed to hard at that.
Yes the episodes are predictable, but as long as you don't overanalyze their format, it doesn't really matter, as what really pull the show forward are House's witty remarks.